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Ingredient file // Vitamin or mineral

Pyridoxine Hydrochloride

A needed vitamin, not a wellness boost

Pyridoxine hydrochloride is a manufactured form of vitamin B6 added to help food meet its nutrient target. Dogs need B6 for normal growth and blood production. Its presence on a label is no reason to expect a benefit from extra B6.

Role in the food Supporting nutrient
What it is
A manufactured, crystalline form of vitamin B6 that supplies a measured amount of the nutrient to food.
Made from
Chemically synthesized starting compounds
Main job
Supplies vitamin B6
Typical amount
Not published
Watch for
Separate high-dose B6 supplements
Not the same as
Pyridoxal or pyridoxamine

Straight answer

Is Pyridoxine Hydrochloride safe for dogs?

Read it as a vitamin supply line

Pyridoxine hydrochloride near the end of an ingredient list is doing a small, necessary job. Its position cannot tell you the finished B6 level. Check that the food is complete for your dog's life stage, and do not use the listing as a reason to add a B6 supplement.

Why it is in the food
Supplies vitamin B6

Our read // In our catalog

In 1 of every 1 foods we track

Share of foods that list it

81%

2,585 of the 3,204 foods with an ingredient list on file, from 89 brands. 1,715 dry dog food, 776 wet dog food, 39 dog food topper.

Each square is 1% of the catalog

Where it sits on the label

Median position 23. In the top five of 2 foods, so it is usually a minor ingredient.

Top five List position, heaviest first

Above the salt

8%

Usually listed after the salt, which caps it at roughly 1% of the recipe in 92% of foods.

Price per lb

Foods with it $3.17
All foods $3.25

Median of the cheapest bag price across 1,469 priced foods, about level with the catalog. The price is the food's, not the ingredient's.

Who leans on it

7%

of the foods that list it are from Purina. 89 brands use it in total.

The story

How a 1930s rat cure became a dog food vitamin

Vitamin B6 started as an unknown factor in rat experiments. In 1934, Paul György showed that the factor curing a rat condition called acrodynia was a distinct vitamin. Samuel Lepkovsky isolated and crystallized it in 1938. The next year, Harris and Karl Folkers, and separately Richard Kuhn's group, worked out its chemical structure, and György named the compound pyridoxine.11

Dogs were part of the early research. In 1946, Sarma, Snell and Elvehjem injected B6-deficient dogs with pyridoxine or one of its 2 natural relatives, pyridoxal and pyridoxamine. All 3 were equally good at restoring growth and blood. Pyridoxine hydrochloride made by chemical synthesis was authorized in the EU as a feed additive for all animal species in 2011, and a 2020 EFSA review found it safe for them at commercial use levels.1,6,15

What it is

How it is made

Vitamin manufacturers synthesize this ingredient rather than extracting it from food. One published route builds pyridoxine from chemical starting materials, forms its hydrochloride salt, and purifies it for use in feed.6,7

  1. 01 // Source Starting compounds One published route starts with purchased L-alanine and oxalic acid, rather than an extracted food material.
  2. 02 // Process Build an intermediate Chemical reactions turn the starting materials into an oxazole intermediate used to build pyridoxine.
  3. 03 // Process Form pyridoxine Further reactions form the vitamin from the oxazole intermediate in the published synthesis.
  4. 04 // Process Form the salt A final salt-forming step produces pyridoxine hydrochloride before purification.
  5. 05 // Output Dry vitamin powder The finished feed ingredient is a white to yellowish powder ready for blending into a vitamin mix.

What is in it

Composition, dry matter

82

% pyridoxine

About this much of the dry salt is pyridoxine itself. Most of the remaining weight is its chloride component.

Pyridoxine 81.4-83.1%9
Chloride 16.9-17.6%9
Pyridoxine hydrochloride assay 99-101%9

These are supplier specification limits for the dry ingredient, not an analysis of finished dog food. The assay measures the whole salt; pyridoxine and chloride measure its components, so do not add all three rows.9

Benefits

What it does for your dog

Each benefit carries the same evidence grade as the claims below.

  1. 01

    Protein put to use

    PLP works with more than 100 enzymes, many of which handle amino acids from dietary protein. The support is essential biochemistry. No dog trial shows that extra B6 in a complete food improves protein use.14

    1. Strong
    2. Some
    3. Thin
    4. None
  2. 02

    Normal brain messenger supply

    PLP is needed to make serotonin and dopamine. One study found lower blood B6 in dogs with epilepsy, but no trial shows that the B6 in food prevents seizures or calms dogs.13,14

    1. Strong
    2. Some
    3. Thin
    4. None

Why it is in the bag

A real vitamin source, even at the list's end

  1. Main nutrition
  2. Supporting nutrient
  3. Does a job
  4. Mostly filler

Makers add it so a complete food reaches the B6 minimum AAFCO sets for dogs. B6 works with over 100 enzymes, many of them handling protein. It sits near the end of the list because labels rank ingredients by weight and a vitamin is needed in tiny amounts. Low placement does not make it filler. It is there to supply a nutrient, not bulk, though extra B6 beyond the requirement adds no proven benefit.1,5,10,14

  1. 01

    Meets a vitamin target

    Manufacturers add a measured B6 source so the finished food meets its nutrient target. AAFCO sets a pyridoxine minimum for complete dog food.5,6

  2. 02

    Allows for processing losses

    A swine-feed experiment found incomplete B6 recovery after extrusion and better recovery from an encapsulated form. Its tested extrusion temperatures and pelleting settings did not significantly change B6 recovery.8

  3. 03

    Supplies a standard powder

    An industrial synthesis route increased pyridoxine output and lowered its cost. Chemical manufacture supplies a concentrated ingredient that makers can measure into vitamin mixes.6,7

How much AAFCO sets a finished dog food minimum of 1.5 mg pyridoxine per kg of dry matter for growth and adult maintenance, but specifies no amount of this ingredient.5

Our read // The claims

What the evidence supports

Strong: controlled studies in dogs agree. Some: small or mixed dog data. Thin: mechanism or lab work only. None: nothing, or the evidence points the other way.

  1. Vets say

    Dogs need vitamin B6 for normal growth

    Evidence

    1. Strong
    2. Some
    3. Thin
    4. None

    In a 3-puppy depletion study, restoring B6 improved growth and blood measures. AAFCO sets a minimum for complete dog food. These findings support meeting the requirement, not giving extra B6 to a dog already eating a complete diet.1,5

  2. Owners say

    Vitamin B6 stops milk in false pregnancy

    Outruns the evidence

    Evidence

    1. Strong
    2. Some
    3. Thin
    4. None

    A 40-dog trial tested daily pyridoxine hydrochloride at 50 mg per kg of body weight. Milk stopped in 10 of 10 dogs at that dose, versus 2 of 10 on placebo. Ordinary food fortification is not that treatment.2,5

  3. Brands say

    Added B6 calms anxious dogs

    Outruns the evidence

    Evidence

    1. Strong
    2. Some
    3. Thin
    4. None

    A 21-dog trial tested a supplement containing B6, oils, vitamin E and herbs. Some behavior measures improved, but the trial cannot identify B6 as the cause. The supplement maker funded the study.3

  4. Owners say

    Water-soluble B6 is harmless at any dose

    Outruns the evidence

    Evidence

    1. Strong
    2. Some
    3. Thin
    4. None

    Beagles given 300 mg per kg of body weight daily by mouth developed a swaying gait within 9 days, followed by sensory nerve damage. That dose is far beyond food fortification, but any-dose safety is false.4,6

The research

Studies worth knowing

Published research we read for this page, dog studies first.

  1. 1946 // Injection trial, 3 B6 forms

    Dogs used all 3 forms of B6 equally well15

    Vitamin B6-deficient dogs

    Found. Researchers injected pyridoxine, pyridoxal or pyridoxamine into the veins of dogs lacking B6. All 3 forms were equally active at restoring growth and rebuilding blood.

    What it means. Pyridoxine, the form on the label, works as real B6 for dogs, although this test skipped digestion.

  2. 2021 // Treatment trial, 4 groups

    A high dose of B6 stopped false pregnancy milk like a drug16

    40 female dogs with false pregnancy

    Found. Dogs got 10 or 50 mg per kg of pyridoxine hydrochloride daily, cabergoline or a placebo for 20 days. The 50 mg dose stopped milk as well as cabergoline did, and the researchers found no side effects.

    What it means. This is a short course of a treatment dose. It says nothing about the small amount of B6 a complete food supplies.

  3. 2007 // Feeding trial, 4 vitamin levels

    Pet dogs' blood B6 shifted on set vitamin diets12

    64 privately owned adult dogs

    Found. Dogs switched from ordinary commercial foods to diets with graded vitamin amounts for 122 days. Blood pyridoxal 5'-phosphate, the active B6, was partially reduced by the end, and coat and hair did not change.

    What it means. Blood B6 responds to diet, but this trial gives no sign that more B6 improves a healthy dog's coat.

  4. 2025 // Blood comparison study

    Dogs with epilepsy had lower blood B613

    49 dogs with epilepsy, 39 healthy dogs

    Found. Researchers profiled plasma from 49 dogs with idiopathic epilepsy and 39 healthy dogs. Vitamin B6 was significantly lower in the dogs with epilepsy, along with changes in markers of oxidative stress and amino acid metabolism.

    What it means. This links low B6 with epilepsy but cannot show cause. It does not support giving B6 for seizures.

Straight answers

What owners ask

  1. Q01

    Is it just filler?

    No

    It supplies vitamin B6, which dogs need in small amounts. It adds no meaningful bulk to a recipe. Its place near the end of an ingredient list is expected for a vitamin.1,5,10

  2. Q02

    Does hydrochloride mean harmful acid?

    No

    Hydrochloride names the salt form of pyridoxine. The feed ingredient is a purified powder, and chloride is part of its measured chemical composition.6,9

  3. Q03

    Can the list tell me its dose?

    No

    The ingredient list ranks items by weight but gives no individual amounts. Check the nutritional adequacy statement for your dog's life stage. If you need the finished food's B6 level, ask its maker.5,10

Who uses it

Brands, best sellers and the company it keeps

Top brands, by foods that list it

  1. Purina 180 / 185
  2. Blue 167 / 186
  3. Royal Canin 158 / 160
  4. Hill's 115 / 116
  5. Wellness 100 / 118
  6. Merrick 94 / 107
  7. NutriSource 88 / 91
  8. Nulo 84 / 117
  9. Stella & Chewy's 75 / 85
  10. Nutro 69 / 71

Foods that list it / all the brand's recipes we track.

Plus 79 more brands.

Amazon best sellers that list it

  1. #1 Blue Life Protection Formula Adult Chicken and Brown Rice Recipe Dry Dog Food
  2. #2 Purina One SmartBlend Adult Dog Lamb & Rice Formula Dry Dog Food
  3. #3 Purina Pro Plan Adult Complete Essentials Shredded Blend Chicken & Rice Formula Dry Dog Food
  4. #4 Hill’s Science Diet Light Small & Mini Chicken Recipe Dry Dog Food
  5. #5 Blue Life Protection Formula Adult Small Breed Chicken and Brown Rice Recipe Dry Dog Food
  6. #6 Hill’s Science Diet Adult Sensitive Stomach & Skin Chicken Recipe Dry Dog Food
  7. #7 Stella & Chewy’s Marie’s Magical Dinner Dust Cage-Free Chicken Recipe Freeze-Dried Raw Dog Food Topper
  8. #8 Diamond Naturals Skin & Coat Formula All Life Stages Salmon & Potato Formula Dry Dog Food

Rank on Amazon's dog food best seller list, checked October 2026.

Usually listed with, share of the foods that list it

  1. Chicken 42%
  2. Mixed Tocopherols 39%
  3. Chicken Fat 35%
  4. Natural Flavor 35%
  5. Peas 31%
  6. Flaxseed 27%
  7. Chicken Meal 27%
  8. Brown Rice 23%
  9. Carrots 18%
  10. Sweet Potatoes 16%
  11. Dried Plain Beet Pulp 16%
  12. Potatoes 16%

On the shelf

Foods that list Pyridoxine Hydrochloride

2,585 foods in our catalog list it. These 60 list it highest on the label.

Purina Beyond Mixers+ Immune Support Chicken Bone Broth Dog Food TopperPurinaPurina Beyond Mixers+ Immune Support Chicken Bone Broth Dog Food TopperTopper // No. 2 on the labelEvanger’s Super Premium Heritage Classic Chicken & Rice Dog Food TopperEvanger'sEvanger’s Super Premium Heritage Classic Chicken & Rice Dog Food TopperTopper // No. 5 on the labelDave’s Pet Food Restricted Diet Sodium Wet Dog FoodDave's Pet FoodDave’s Pet Food Restricted Diet Sodium Wet Dog FoodWet // No. 6 on the labelEvanger’s Grain Free Braised Beef Chunks with Gravy - packed by hand! Wet Dog FoodEvanger'sEvanger’s Grain Free Braised Beef Chunks with Gravy - packed by hand! Wet Dog FoodWet // No. 6 on the labelTruDog Elevate Smoky BBQ Stew Grain Free Shredded Chicken Stew w/ Sweet Potat Wet Dog FoodTruDogTruDog Elevate Smoky BBQ Stew Grain Free Shredded Chicken Stew w/ Sweet Potat Wet Dog FoodWet // No. 7 on the labelBixbi Rawbble Grain-Free Freeze-Dried Dog FoodBIXBIBixbi Rawbble Grain-Free Freeze-Dried Dog FoodFreeze-Dried // No. 7 on the labelAgainst the Grain The Good Egg - Steak ‘n Egg Wet Dog FoodAgainst the GrainAgainst the Grain The Good Egg - Steak ‘n Egg Wet Dog FoodWet // No. 7 on the labelAgainst the Grain The Good Egg - Bacon N Eggs Scramble Wet Dog FoodAgainst the GrainAgainst the Grain The Good Egg - Bacon N Eggs Scramble Wet Dog FoodWet // No. 7 on the labelHalo Elevate Smoky BBQ Stew Grain Free Shredded Chicken Stew w/ Sweet Potat Wet Dog FoodHaloHalo Elevate Smoky BBQ Stew Grain Free Shredded Chicken Stew w/ Sweet Potat Wet Dog FoodWet // No. 7 on the labelZignature Inception Chicken Recipe Food Can Wet Dog FoodZignatureZignature Inception Chicken Recipe Food Can Wet Dog FoodWet // No. 7 on the labelZignature Inception Pork Recipe Food Can Wet Dog FoodZignatureZignature Inception Pork Recipe Food Can Wet Dog FoodWet // No. 8 on the labelNatural Balance Platefulls Tender Carrot, Potato & Beef Recipe Wet Dog FoodNatural BalanceNatural Balance Platefulls Tender Carrot, Potato & Beef Recipe Wet Dog FoodWet // No. 8 on the label
Show 48 more
Evanger’s Heritage Classic Lamb & Rice Dinner Wet Dog FoodEvanger'sEvanger’s Heritage Classic Lamb & Rice Dinner Wet Dog FoodWet // No. 6 on the labelEvanger’s Roasted Chicken Drummet Dinner - packed by hand! Grain-Free Wet Dog FoodEvanger'sEvanger’s Roasted Chicken Drummet Dinner - packed by hand! Grain-Free Wet Dog FoodWet // No. 6 on the labelEvanger’s EVX Restricted Diet: Weight Management Wet Dog FoodEvanger'sEvanger’s EVX Restricted Diet: Weight Management Wet Dog FoodWet // No. 6 on the labelEvanger’s Heritage Classic Senior & Weight Management Wet Dog FoodEvanger'sEvanger’s Heritage Classic Senior & Weight Management Wet Dog FoodWet // No. 7 on the labelEvanger’s Super Premium EVX Restricted Diet: Skin & Coat Wet Dog FoodEvanger'sEvanger’s Super Premium EVX Restricted Diet: Skin & Coat Wet Dog FoodWet // No. 7 on the labelEvanger’s Chunky Chicken Casserole - packed by hand! Wet Dog FoodEvanger'sEvanger’s Chunky Chicken Casserole - packed by hand! Wet Dog FoodWet // No. 8 on the labelEvanger’s EVX Restricted Diet: Digestion Bland Diet Wet Dog FoodEvanger'sEvanger’s EVX Restricted Diet: Digestion Bland Diet Wet Dog FoodWet // No. 8 on the labelPurina Pro Plan Sport Adult High Protein Beef & Bison Entrée Classic Wet Dog FoodPurinaPurina Pro Plan Sport Adult High Protein Beef & Bison Entrée Classic Wet Dog FoodWet // No. 8 on the labelZignature Inception Pork Formula Dry Dog FoodZignatureZignature Inception Pork Formula Dry Dog FoodDry // No. 8 on the labelWysong Archetype Burgers Freeze-Dried Raw Dog FoodWysongWysong Archetype Burgers Freeze-Dried Raw Dog FoodFreeze-Dried // No. 8 on the labelWellness Core 95% Turkey & Spinach Grain-Free Wet Dog FoodWellnessWellness Core 95% Turkey & Spinach Grain-Free Wet Dog FoodWet // No. 9 on the labelWellness Core 95% Chicken & Broccoli Grain-Free Wet Dog FoodWellnessWellness Core 95% Chicken & Broccoli Grain-Free Wet Dog FoodWet // No. 9 on the labelEvanger’s Grain Free LID Venison + Beef Dinner Wet Dog FoodEvanger'sEvanger’s Grain Free LID Venison + Beef Dinner Wet Dog FoodWet // No. 9 on the labelZignature Essence LIR Landfowl Recipe Food Can Grain-Free Wet Dog FoodZignatureZignature Essence LIR Landfowl Recipe Food Can Grain-Free Wet Dog FoodWet // No. 9 on the labelZignature Inception Fish Recipe Food Can Wet Dog FoodZignatureZignature Inception Fish Recipe Food Can Wet Dog FoodWet // No. 9 on the labelNatural Balance Platefulls Savory Duck & Pumpkin Recipe Wet Dog FoodNatural BalanceNatural Balance Platefulls Savory Duck & Pumpkin Recipe Wet Dog FoodWet // No. 9 on the labelThe Honest Kitchen Tender Turkey One Pot Stew Wet Dog FoodThe Honest KitchenThe Honest Kitchen Tender Turkey One Pot Stew Wet Dog FoodWet // No. 9 on the labelThe Honest Kitchen Slow Cooked Chicken One Pot Stew Wet Dog FoodThe Honest KitchenThe Honest Kitchen Slow Cooked Chicken One Pot Stew Wet Dog FoodWet // No. 9 on the labelPurina Pro Plan Adult 7+ Senior Complete Essentials Chicken & Rice Entrée Classic Wet Dog FoodPurinaPurina Pro Plan Adult 7+ Senior Complete Essentials Chicken & Rice Entrée Classic Wet Dog FoodWet // No. 9 on the labelZignature Select Cuts Turkey Formula with Super Grains Dry Dog FoodZignatureZignature Select Cuts Turkey Formula with Super Grains Dry Dog FoodDry // No. 9 on the labelZignature Inception Fish Formula Dry Dog FoodZignatureZignature Inception Fish Formula Dry Dog FoodDry // No. 9 on the labelWysong Fundamentals Dry Dog FoodWysongWysong Fundamentals Dry Dog FoodDry // No. 9 on the labelGather Free Acres Organic Free-Run Chicken Recipe for Adult Dogs Grain-Free Dry Dog FoodGatherGather Free Acres Organic Free-Run Chicken Recipe for Adult Dogs Grain-Free Dry Dog FoodDry // No. 9 on the labelPurina Beneful Chicken & Carrots Loaf Wet Dog FoodPurinaPurina Beneful Chicken & Carrots Loaf Wet Dog FoodWet // No. 10 on the labelMerrick Fresh Selects Turkey & Brown Rice Fresh Frozen Dog FoodMerrickMerrick Fresh Selects Turkey & Brown Rice Fresh Frozen Dog FoodFrozen // No. 10 on the labelMerrick Fresh Selects Chicken & Brown Rice Fresh Frozen Dog FoodMerrickMerrick Fresh Selects Chicken & Brown Rice Fresh Frozen Dog FoodFrozen // No. 10 on the labelDave’s Pet Food Bland Diet Pouches Dave’s Bland Duck & Pumpkin Pouch Recipe for Dogs / 10 Pack - Pou Wet Dog FoodDave's Pet FoodDave’s Pet Food Bland Diet Pouches Dave’s Bland Duck & Pumpkin Pouch Recipe for Dogs / 10 Pack - Pou Wet Dog FoodWet // No. 10 on the labelGravy Train Ground Dinner With Chicken Wet Dog FoodGravy TrainGravy Train Ground Dinner With Chicken Wet Dog FoodWet // No. 10 on the labelEvanger’s EVX Restricted Diet: Hip & Joint and Senior Support Grain-Free Wet Dog FoodEvanger'sEvanger’s EVX Restricted Diet: Hip & Joint and Senior Support Grain-Free Wet Dog FoodWet // No. 10 on the labelZignature Essence LIR Ranch Recipe Food Can Grain-Free Wet Dog FoodZignatureZignature Essence LIR Ranch Recipe Food Can Grain-Free Wet Dog FoodWet // No. 10 on the labelZignature Original Food Lamb Formula Grain-Free Wet Dog FoodZignatureZignature Original Food Lamb Formula Grain-Free Wet Dog FoodWet // No. 10 on the labelZignature Original Food Turkey Formula Grain-Free Wet Dog FoodZignatureZignature Original Food Turkey Formula Grain-Free Wet Dog FoodWet // No. 10 on the labelThe Honest Kitchen Roasted Beef One Pot Stew Wet Dog FoodThe Honest KitchenThe Honest Kitchen Roasted Beef One Pot Stew Wet Dog FoodWet // No. 10 on the labelOpen Farm Icelandic Cod & Herring Grain-Free Wet Dog FoodOpen FarmOpen Farm Icelandic Cod & Herring Grain-Free Wet Dog FoodWet // No. 10 on the labelInstinct Freshly Crafted Meals Cage-Free Chicken Recipe Wet Dog FoodInstinctInstinct Freshly Crafted Meals Cage-Free Chicken Recipe Wet Dog FoodWet // No. 10 on the labelPurina Beneful Freshly Prepared Stews Turkey Dinner with Spinach and Ditalini Pasta in Gravy Wet Dog FoodPurinaPurina Beneful Freshly Prepared Stews Turkey Dinner with Spinach and Ditalini Pasta in Gravy Wet Dog FoodWet // No. 10 on the labelPurina Beneful Freshly Prepared Stews Chicken Dinner with Carrots and Rice in Gravy Wet Dog FoodPurinaPurina Beneful Freshly Prepared Stews Chicken Dinner with Carrots and Rice in Gravy Wet Dog FoodWet // No. 10 on the labelBlue Wilderness Wild Meals Chicken & Sweet Potato Wet Dog FoodBlueBlue Wilderness Wild Meals Chicken & Sweet Potato Wet Dog FoodWet // No. 10 on the labelFirstMate Pacific Ocean Fish Large Breed Formula Grain-Free Dry Dog FoodFirstMateFirstMate Pacific Ocean Fish Large Breed Formula Grain-Free Dry Dog FoodDry // No. 10 on the labelFirstMate Pacific Ocean Fish Meal Original Formula Grain-Free Dry Dog FoodFirstMateFirstMate Pacific Ocean Fish Meal Original Formula Grain-Free Dry Dog FoodDry // No. 10 on the labelZignature Essence LIR Landfowl Recipe Dry Dog FoodZignatureZignature Essence LIR Landfowl Recipe Dry Dog FoodDry // No. 10 on the labelZignature Inception Chicken Formula Dry Dog FoodZignatureZignature Inception Chicken Formula Dry Dog FoodDry // No. 10 on the labelZignature Original Turkey Formula with Probiotics Grain-Free Dry Dog FoodZignatureZignature Original Turkey Formula with Probiotics Grain-Free Dry Dog FoodDry // No. 10 on the labelZignature Original Small Bites Turkey Formula with Probiotics Grain-Free Dry Dog FoodZignatureZignature Original Small Bites Turkey Formula with Probiotics Grain-Free Dry Dog FoodDry // No. 10 on the labelRoyal Canin Veterinary Selected Protein PW Moderate Calorie Grain-Free Dry Dog FoodRoyal CaninRoyal Canin Veterinary Selected Protein PW Moderate Calorie Grain-Free Dry Dog FoodDry // No. 10 on the labelWellness Core Six Free-Range Lamb Grain-Free Dry Dog FoodWellnessWellness Core Six Free-Range Lamb Grain-Free Dry Dog FoodDry // No. 10 on the labelWellness Core Six Cage-Free Duck Grain-Free Dry Dog FoodWellnessWellness Core Six Cage-Free Duck Grain-Free Dry Dog FoodDry // No. 10 on the labelNature’s Recipe Healthy Skin Vegetarian Recipe Dry Dog FoodNature's RecipeNature’s Recipe Healthy Skin Vegetarian Recipe Dry Dog FoodDry // No. 10 on the label

Sources

What we read

Checked September 1, 2026.

  1. 1 The vitamin B6 group; comparative growth and anti-anemic potencies of pyridoxal, pyridoxamine and pyridoxine for dogs Experimental Biology and Medicine, 1946 // Journal
  2. 2 Use of pyridoxine hydrochloride in the interruption of lactation in female dogs with pseudopregnancy Animal Reproduction, 2021 // Journal
  3. 3 Effects of a Nutritional Supplement (DìRelaxTM) on Anxiety in Dogs in a Randomized Control Trial Design Animals, 2022 // Journal
  4. 4 Pyridoxine megavitaminosis produces degeneration of peripheral sensory neurons (sensory neuronopathy) in the dog Neurotoxicology, 1981 // Journal
  5. 5 AAFCO Dog and Cat Food Nutrient Profiles AAFCO, 2014 // Regulator
  6. 6 Assessment of the application for renewal of authorisation of pyridoxine hydrochloride (vitamin B6) as a feed additive for all animal species EFSA Journal, 2020 // Regulator
  7. 7 Improved Oxazole Method for the Practical and Efficient Preparation of Pyridoxine Hydrochloride (Vitamin B6) Organic Process Research & Development, 2013 // Journal
  8. 8 Evaluation of Extrusion Temperatures, Pelleting Parameters, and Vitamin Forms on Vitamin Stability in Feed Animals, 2020 // Journal
  9. 9 Vitamin b6 hcl_pyridoxine hcl desde 1 kg Nutrifoods, n.d. // Industry
  10. 10 Reading Labels AAFCO, n.d. // Regulator
  11. 11 A History of the Isolation and Identification of Vitamin B6 Annals of Nutrition and Metabolism (Karger), 2012 // Journal
  12. 12 Blood vitamin concentrations in privately owned dogs fed non-standardized commercial diets and after intake of diets with specified vitamin concentrations Journal of Animal Physiology and Animal Nutrition (Europe PMC record), 2007 // Journal
  13. 13 Plasma metabolome reveals altered oxidative stress, inflammation, and amino acid metabolism in dogs with idiopathic epilepsy Epilepsia (Europe PMC record), 2025 // Journal
  14. 14 Vitamin B6 Linus Pauling Institute, Oregon State University, 2024 // University
  15. 15 The vitamin B6 group. IX. Comparative growth and anti-anemic potencies of pyridoxal, pyridoxamine and pyridoxine for dogs (abstract record) Indian Academy of Sciences repository, 1946 // Journal
  16. 16 Use of pyridoxine hydrochloride in the interruption of lactation in female dogs with pseudopregnancy Animal Reproduction (Europe PMC record), 2021 // Journal
An ingredient on its own tells you very little. What matters is how much of it there is and where it sits in the list. That is why we weigh the top five rather than reacting to any single name further down. Back to the wiki

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